Swati Naik, MBBS, on Investigating CD123-CAR T Therapy for Relapsed AML

Video

The assistant member at St. Jude Children’s Research Hospital discussed updated data from a phase 1 study being conducted at the hospital.

"I think that autologous collection is challenging, especially in these patients who have received multiple therapies and are so fragile, it's difficult to collect their cells. So going forward, we are going to have a separate arm in the study, which will be open for patients who previously received a transplant, in which the T cells will be manufactured from the previous transplant donor. Hopefully, that will give us a healthier starting product for the CAR manufacturing.”

CD123-targeted chimeric antigen receptor (CAR) T-cells demonstrated safety, feasibility, and evidence of clinical activity in pediatric patients with refractory/relapsed acute myeloid leukemia (r/r AML) enrolled in a phase 1 clinical trial (NCT04318678) being conducted at St. Jude Children’s Research Hospital. Updated data from the trial were presented by Swati Naik, MBBS, assistant member, bone marrow transplantation and cellular therapy, St. Jude’s, at the 64th American Society of Hematology (ASH) Annual Meeting, held December 10-12, 2022, in New Orleans, Louisiana.

CGTLive spoke with Naik to learn more about the potential of CD123-CAR T-cells to help address unmet needs that remain within the population of pediatric patients with r/r AML. She discussed the preliminary safety and efficacy data presented at the conference and next steps going forward with the study.

Click here to read more coverage of the 2022 ASH meeting.

REFERENCE
Naik S, Madden R, Lipsitt A, et al. Safety and anti-leukemic activity of CD123-CAR T cells in pediatric patients with AML: Preliminary Results from a Phase 1 Trial. Presented at: 64th ASH Annual Meeting, December 10-12, 2022, in New Orleans, Louisiana. Poster #2003
Recent Videos
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Sarah Larson, MD, the medical director of the Immune Effector Cell Therapy Program in the Division of Hematology/Oncology at David Geffen School of Medicine at University of California, Los Angeles (UCLA)
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
David Porter, MD, the director of cell therapy and transplant at Penn Medicine
Georg Schett, MD, vice president research and chair of internal medicine at the University of Erlangen – Nuremberg
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Related Content
© 2025 MJH Life Sciences

All rights reserved.