Gregory W. Roloff, MD, on Assessing Real-World Experience of Brexu-Cel in Adults With B-ALL

“Adult patients with acute lymphoblastic leukemia have experienced improved outcomes in recent years but relapse is still a very common occurrence. Even now we have newer agents...immune based therapies, that had really revolutionized the care of these patients, but relapse is still a problem and the duration of remission that those new therapies provide is not as long as we would hope it to be.”

Adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) treated with commercial brexucabtagene autoleucel (Tecartus; Kite) across US sites had a 90% complete response rate and 82% minimal residual disease negativity rate, according to the Real-World Outcomes Collaborative of CAR T in Adult ALL (ROCCA) study. Investigators saw low rates of severe cytokine release syndrome but a 32% rate of grade 3-4 immune effector cell-associated neurotoxicity syndrome.

The new data from ROCCA were presented at the 2023 American Society of Hematology (ASH) Annual Meeting & Exposition, held December 9-12, in San Diego, California, by Gregory Roloff, MD, chief hematology/oncology fellow, University of Chicago.

CGTLive spoke with Roloff to learn more about the background of the ROCCA study. He discussed the 2021 approval of brexu-cel and how it changed the treatment landscape but emphasized the need to understand the real-world experience of patients receiving, orattempting to receive the chimeric antigen receptor (CAR) T-cell therapy.

REFERENCE

Roloff GW, Aldoss I, Kopmar NE, et al. Brexucabtagene autoleucel in adults with relapsed/refractory B-cell ALL: Outcomes and novel insights from the real-world outcomes collaborative of CAR T in adult ALL (ROCCA). Presented at:ASH 2023 Annual Meeting & Exposition. December 9-12; San Diego, CA. Abstract 1030