Pushing for a New Era in Cardiology: Matt Killeen, PhD

Commentary
Video

Matt Killeen, PhD, chief scientific officer at Renovacor, shares updates on the company's lead candidate, REN-001, an adeno-associated viral vector serotype 9-based gene therapy for the treatment of BAG3-associated dilated cardiomyopathy.

"Given the fact that today's therapies for heart failure and inherited heart diseases really just work around the edges, patients can quickly find themselves exhausting current treatment options and facing the prospect of procedures." —Matt Killeen, PhD, Chief Scientific Officer, Renovacor

As more and more patients become empowered to take control of their individual health, there is increasing emphasis on cardiac screening and genetic testing. One form of genetically driven heart failure, BAG3-associated dilated cardiomyopathy (DCM), has become an area of focus, as there are currently no commercially available targeted treatments.

Researchers at Renovacor are hoping to change that with REN-001, an adeno-associated viral (AAV) vector serotype 9-based gene therapy for the treatment of DCM.

Matt Killeen, PhD, chief scientific officer at Renovacor, joins CGTL to share updates on REN-001, which is in late stage preclinical development, and other candidates in the pipeline, as well as to shed some light on why the company chose to focus on this genetic form of heart disease.

Recent Videos
David Barrett, JD, the chief executive officer of ASGCT
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
David Barrett, JD, the chief executive officer of ASGCT
Alfred L. Garfall, MD, MS, associate professor of medicine (hematology-oncology) and director, Autologous Hematopoietic Cell Transplantation, Cell Therapy and Transplant Program, Hospital of the University of Pennsylvania; and section chief, Multiple Myeloma, Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania,
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Nirav Shah, MD, MSHP, associate professor of medicine, at the Medical College of Wisconsin
Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Related Content
© 2025 MJH Life Sciences

All rights reserved.