The associate professor of medicine at Medical College of Wisconsin discussed trials assessing the dual, CD19/CD20-targeting CAR T therapy.
“We're always trying to improve on the current standard of care. I think that right now CD19 is the current standard of care and a great option for patients. We've been looking at this dual targeting approach to see if we can improve upon that, and so I look forward to this trial data maturing for diffuse large B-cell lymphoma, and for mantle cell, right now it’s a single center study, but we think that these data justify a multicenter phase 2 study."
Zamtocabtagene autoleucel (zamto-cel; Miltenyi Biomedicine), a CD19/CD20-targeting chimeric antigen receptor (CAR) T-cell therapy, demonstrated safety and efficacy in updated data from a single center, phase 1/2 prospective trial (NCT04186520) in patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) as well as data from the multicenter, phase 2 DALY II USA trial (NCT04792489) in patients with R/R diffuse large B-cell lymphoma (DLBCL).
Nirav Shah, MD, associate professor of medicine, Medical College of Wisconsin, presented the data in 2 presentations at the 2023 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR, held February 15-18 in Orlando, Florida. CGTLive spoke with Shah to learn more about zamto-cel and the advantages and research being conducted with dual-targeting CAR T therapies. He outlined the data presented and highlighted the favorable safety profile of the therapy.
Click here for more coverage of the 2023 Tandem Meetings.
News and Expert Insights in Hemophilia Gene Therapy for Bleeding Disorders Awareness Month 2025
March 9th 2025In observance of Bleeding Disorders Awareness Month, held annually in March, catch up on some of the latest news and expert insights in gene therapy for hemophilia, which is among the most common of these disorders.