Gene Therapy for Liver Cancer
Rockville, Md --GenVec has begun a phase I study of its in vivo gene-based product, AdgvCD. 10, in 18 patients with liver metastases of colectoral cancer . An advenovirus vector modified to carry the cytosine deaminase gene will be administered directly into the hepatic tumor. The gene expresses an enzyme that converts 5-fluorocytosine,an oral anti-fungal agent , into the potent anticancer agent 5-fluorouracil.. The conversion occurs only at the site of gene expression, the company said.
Rockville, Md --GenVec has begun a phase I study of its in vivogene-based product, AdgvCD. 10, in 18 patients with liver metastasesof colectoral cancer . An advenovirus vector modified to carrythe cytosine deaminase gene will be administered directly intothe hepatic tumor. The gene expresses an enzyme that converts5-fluorocytosine,an oral anti-fungal agent , into the potent anticanceragent 5-fluorouracil.. The conversion occurs only at the siteof gene expression, the company said.
Alzheimer Disease Awareness Month 2024: Looking Back at a Year of Progress in Cell and Gene Therapy
November 24th 2024In observance of Alzheimer Disease Awareness Month, held annually in November, we took a look back at the past year's news and expert insights in cell and gene therapy for Alzheimer disease.
Evaluating Allogeneic CAR-T P-BCMA-ALLO1 in R/R Multiple Myeloma
November 21st 2024Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center, discussed interim data from the phase 1/1b clinical trial evaluating Poseida's CAR-T.
