Francesca Barone, MD, PhD, on Positive Biomarker, Overall Survival Data With CAN-3110 in High-Grade Glioma

Video

The chief scientific officer at Candel Therapeutics discussed late-breaking data presented at ASGCT 2023.

“We had previously disclosed the data from ARM A, and this is an expansion cohort, where patients prior to the injection of CAN-3110 gets a pretreatment with... We had some animal data that seems to suggest that this pretreatment was making the viral replication more efficient, and [in the trial] we saw results very similar to arm A, so this really works as an independent cohort that confirms our previous data. We have a median overall survival of 12 months, and this exceeds the median overall survival of the approved drugs in this space.”

Data from the first 50 participants with recurrent high-grade glioma (rHGG) treated with a single intratumoral injection of Candel Therapeutics’ CAN-3110 (also known as rQNestin34.5v.2), a Herpes simplex virus-1 oncolytic viral immunotherapy, tolerated the treatment well and had promising signals of efficacy and survival benefits.

These data, from a phase 1/2 study (NCT03152318), were presented during a late-breaking session at the American Society of Gene and Cell Therapy (ASGCT) 2023 Annual Meeting, held May 16-20, in Los Angeles, California, by Francesca Barone, MD, PhD, chief scientific officer, Candel Therapeutics.

CGTLive spoke with Barone to learn more about the new data seen with CAN-3110 treatment in patients with rHGG. She shared some highlights from her presentation, including a 12-month median overall survival, which is higher than that seen with approved drugs in the space. She also discussed positive biomarker data from the study, such as finding vectors from CAV-3110 within non-injected, shrinking, tumor lesions.

Click here to read more coverage of ASGCT 2023.

REFERENCE
Barone F, Ling A, Solomon IH, et al. Safety and survival outcomes in recurrent high-grade glioma patients treated with CAN-3110, a first-in-class ICP34.5 expressing oncolytic HSV1. News release. Presented at: ASGCT 2023 Annual Meeting; May 16-20; Los Angeles, California.
Recent Videos
Robert Califf, MD, MACC, a cardiologist and former FDA commissioner
Natalie Goedeker, CPNP, on Handling Neuromuscular Gene Therapy at Real-World Sites
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
Michael Flanagan, PhD, chief scientific officer at Avidity
David Barrett, JD, the chief executive officer of ASGCT
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
David Barrett, JD, the chief executive officer of ASGCT
Alfred L. Garfall, MD, MS, associate professor of medicine (hematology-oncology) and director, Autologous Hematopoietic Cell Transplantation, Cell Therapy and Transplant Program, Hospital of the University of Pennsylvania; and section chief, Multiple Myeloma, Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania,
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Nirav Shah, MD, MSHP, associate professor of medicine, at the Medical College of Wisconsin
© 2025 MJH Life Sciences

All rights reserved.