Combining RNA and CAR T-Cell Therapy for Myasthenia Gravis

Video

Michael Singer, MD, PhD, cofounder and chief scientific officer of Cartesian Therapeutics, discussed the company’s lead candidate, Descartes-08.

“We've even been able to administer these CAR T-cells in outpatient settings and in regional hospitals, apart from large medical centers. So, on one hand, we're trying to make CAR T and other engineered cell therapies available beyond oncology, and we're also trying to make them available beyond large medical centers and outside of the inpatient environment.”

Myasthenia gravis is a spontaneous, rare, neuromuscular autoimmune disorder characterized by muscle weakness and fatigue. Cartesian Therapeutics is developing an RNA chimeric antigen receptor (CAR) T-cell therapy, Descartes-08, for the potential treatment of the disease.

Descartes-08 is directed against B-cell Maturation Antigen and is being evaluated in a phase 1/2 study (NCT04146051). Interim data from the study previously showed improvements on the Myasthenia Gravis Foundation of America Clinical Classification and Myasthenia Gravis Composite scales.

CGTLive spoke with Michael Singer, MD, PhD, cofounder chief scientific officer, Cartesian, to learn more about Descartes-08 and the advantages of a combination RNA/CAR T-cell therapy. He discussed its mechanism of action as well as its potential in other rare conditions.

REFERENCE
Cartesian Therapeutics announces clinical responses in first cohort of phase 1b/2a trial in myasthenia gravis. News release. Cartesian Therapeutics. August 24, 2021. https://www.cartesiantherapeutics.com/cartesian-therapeutics-announces-clinical-responses-in-first-cohort-of-phase-1b-2a-trial-in-myasthenia-gravis/
Recent Videos
Matthew Wicklund, MD, a professor of neurology at the University of Texas Health Science Center San Antonio
Matthew Wicklund, MD, a professor of neurology at the University of Texas Health Science Center San Antonio
Renier Brentjens, MD, PhD, the chair of the department of medicine and the deputy director at Roswell Park Comprehensive Cancer Center
Renier Brentjens, MD, PhD, the chair of the department of medicine and the deputy director at Roswell Park Comprehensive Cancer Center
Renier Brentjens, MD, PhD, the chair of the department of medicine and the deputy director at Roswell Park Comprehensive Cancer Center
Renier Brentjens, MD, PhD, the chair of the department of medicine and the deputy director at Roswell Park Comprehensive Cancer Center
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
Robert Califf, MD, MACC, a cardiologist and former FDA commissioner
Natalie Goedeker, CPNP, on Handling Neuromuscular Gene Therapy at Real-World Sites
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
© 2025 MJH Life Sciences

All rights reserved.