Challenges With CAR T Therapy in Multiple Myeloma: Larry D. Anderson Jr, MD, PhD

Video

The associate professor from the UT Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center discussed the challenges faced with CAR T-cell therapy in patients with multiple myeloma.

This content originally appeared on our sister site, OncLive.

OncLive spoke with Larry Anderson, MD, PhD, associate professor, Department of Internal Medicine, Division of Hematology/Oncology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, about the challenges faced with CAR T-cell therapy in patients with multiple myeloma.

CAR T-cell therapy, although having demonstrated efficacy in multiple myeloma, comes with some associated toxicities that must be addressed. Because of this, Anderson said, CAR T-cell therapy availability is currently limited to large referral centers, such as bone marrow transplant centers or academic medical centers that have expertise in stem cell and cell therapies.

Additionally, CAR T-cell therapy often requires a multidisciplinary team comprised of social workers, caregivers, and others, Anderson says. After receiving CAR T-cell therapy, patients cannot drive for 2 months due to the risk of neurotoxicity and seizures; as such, patients receiving this modality may require a caregiver. Moreover, due to fevers or other symptoms of cytokine release syndrome, other medical professionals a patient visits will need to be made aware of the treatment, Anderson adds. Additionally, patients generally need to live within hours of their treatment center for at least the first month of therapy, which could impact their lifestyle, according to Anderson.

However, the challenges faced with CAR T-cell therapy are often balanced out by the freedom of not needing to be on additional treatment for the coming years, Anderson concludes.

Recent Videos
David Barrett, JD, the chief executive officer of ASGCT
David-Alexandre C. Gros, MD, Eledon’s chief executive officer
David Barrett, JD, the chief executive officer of ASGCT
Alfred L. Garfall, MD, MS, associate professor of medicine (hematology-oncology) and director, Autologous Hematopoietic Cell Transplantation, Cell Therapy and Transplant Program, Hospital of the University of Pennsylvania; and section chief, Multiple Myeloma, Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania,
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Nirav Shah, MD, MSHP, associate professor of medicine, at the Medical College of Wisconsin
Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center
Reena Sharma, MD, an adult metabolic consultant at Salford Royal Hospital
Mark Hamilton, MD, PhD, a hematology-oncology and bone marrow transplant (BMT) cell therapy fellow at Stanford University
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Related Content
© 2025 MJH Life Sciences

All rights reserved.