CGTLive’s Weekly Rewind – September 9, 2022

Article

Review top news and interview highlights from the week ending September 9, 2022.

Welcome to CGTLive’s Weekly Rewind! We’ve compiled 5 highlights from this week’s coverage of advances in gene and cell therapies, including FDA actions, notable research, and interviews with experts across the field.

1. CAR T/CARVac Therapy Yields Responses in Refractory Testicular Cancer

BNT211 showed encouraging responses in testicular cancer but less encouraging responses in ovarian cancer.

2. Sequential T-Cell Redirection Therapies Yield Deep, Durable Responses in R/R Multiple Myeloma

Patients receiving CAR T-cell therapy or bispecific antibody therapies as first salvage therapy had an ORR of 84%.

3. Mark Forman, MD, PhD, on Genetic Testing and Further Research in Frontotemporal Dementia

The chief medical officer of Passage Bio discussed research needs in FTD.

4. Polycythemia Vera mRNA Therapy Receives FDA Fast Track Designation

SLN124 was well-tolerated in a previous clinical trial involving healthy volunteers.

5. Ornithine Transcarbamylase Gene Editing Program Nabs Another FDA Designation

iECURE is planning to submit an IND for GTP-506 in mid-2023.

Recent Videos
Barry J Byrne, MD, PhD, the chief medical advisor of MDA and a physician-scientist at the University of Florida
Sarah Larson, MD, the medical director of the Immune Effector Cell Therapy Program in the Division of Hematology/Oncology at David Geffen School of Medicine at University of California, Los Angeles (UCLA)
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Ben Samelson-Jones, MD, PhD, assistant professor pediatric hematology, Perelman School of Medicine, University of Pennsylvania and Associate Director, Clinical In Vivo Gene Therapy, Children’s Hospital of Philadelphia
Manali Kamdar, MD, the associate professor of medicine–hematology and clinical director of lymphoma services at the University of Colorado
Steven W. Pipe, MD, a professor of pediatric hematology/oncology at CS Mott Children’s Hospital
Haydar Frangoul, MD, the medical director of pediatric hematology/oncology at Sarah Cannon Research Institute and Pediatric Transplant and Cellular Therapy Program at TriStar Centennial
Bhagirathbhai R. Dholaria, MD, an associate professor of medicine in malignant hematology & stem cell transplantation at Vanderbilt University Medical Center
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